Specialists from Russia‘s Baltic Federal University proposed today coating gold and platinum nanoparticles with a natural amino acid to make MRI contrast agents safer.
The scientists explained in an article published Monday in the journal Molecular Liquids that MRIs typically use heavy metal-based contrast agents. Which can be toxic to the body’s cells.
To improve their biocompatibility, the researchers camouflaged gold and platinum nanoparticles with a layer of the natural amino acid L-tyrosine. Since this amino acid is naturally present in humans. The body’s cells more readily accept these hidden particles.
Researcher Mark Smirnov explained that the interaction of tyrosine with gold nanoparticles causes the molecule to compress. While the interaction with platinum nanoparticles causes it to stretch. Platinum is currently considered a promising anticancer agent. But its interaction with amino acids has not been previously studied.
According to Smirnov, further research on these nanoparticles will enable the development of new biomedical solutions. He notes that these approaches will improve the immune system’s response. Paving the way for new therapeutic strategies.
The research team is currently working with another amino acid, tryptophan, and is testing gold nanoparticles in various shapes: rods, stars, and spheres.
This could expand the scope of safe contrast agents and accelerate the development of new diagnostic and therapeutic methods.
With information from Prensa Latina
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